Leptin signaling and cancer chemoresistance: Perspectives
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چکیده
منابع مشابه
Leptin signaling and cancer chemoresistance: Perspectives
Obesity is a major health problem and currently is endemic around the world. Obesity is a risk factor for several different types of cancer, significantly promoting cancer incidence, progression, poor prognosis and resistance to anti-cancer therapies. The study of this resistance is critical as development of chemoresistance is a serious drawback for the successful and effective drug-based trea...
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Leptin is secreted by adipose tissue and regulates energy homeostasis, glucose and lipid metabolism, immune function, and other systems. The binding of leptin to its specific receptor activates various intracellular signaling pathways, including Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3), insulin receptor substrate (IRS)/phosphatidylinositol 3 kinase (PI3K...
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ژورنال
عنوان ژورنال: World Journal of Clinical Oncology
سال: 2017
ISSN: 2218-4333
DOI: 10.5306/wjco.v8.i2.106